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role of oxidative stress in stem, cancer, and cancer stem cells氧化应激在干细胞中的作用、癌症和癌症干细胞.pdf

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role of oxidative stress in stem, cancer, and cancer stem cells氧化应激在干细胞中的作用、癌症和癌症干细胞

Cancers 2010, 2, 859-884; doi:10.3390/cancers2020859 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho * Department of Animal Biotechnology (BK21), RCTCP, and Animal Resources Research Center, Konkuk University, Seoul 143-701, Korea; E-Mails: ahmed_morsy86@ (A.A.D.); hyeon@konkuk.ac.kr (H.-Y.C.); nataskjh@konkuk.ac.kr (J.-H.K.) * Author to whom correspondence should be addressed; E-Mail: ssangoo@konkuk.ac.kr; Tel.: +82-2-450-4207; Fax: +82-2-455-1044. Received: 4 March 2010; in revised form: 12 April 2010 / Accepted: 6 May 2010 / Published: 17 May 2010 Abstract: The term ‘‘oxidative stress” refers to a cell’s state characterized by excessive production of reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory mechanisms for stem, cancer, and cancer stem cells. The concept of cancer stem cells arose from observations of similarities between the self-renewal mechanism of stem cells and that of cancer stem cells, but compared to normal stem cells, they are believed to have no control over the cell number. ROS have been implicated in diverse processes in various cancers, and generally the increase of ROS in cancer cells is known to play an important role in the initiation and progression of cancer. Additionally, ROS have been considered as the most significant mutagens in stem cells; when elevated,