revisiting the relationship between baseline risk and risk under treatment回顾基线风险和风险接受治疗之间的关系.pdfVIP

Emerging Themes in Epidemiology BioMed Central Hypothesis Open Access Revisiting the relationship between baseline risk and risk under treatment 1 2 2 Hao Wang , Jean-Pierre Boissel and Patrice Nony* Address: 1Pharmacology Department, Shanghai Second Medical University, Shanghai, PR China and 2Clinical Pharmacology Department, UMR CNRS 5558 Claude Bernard University Lyon 1, Cardiovascular Hospital, Lyon, France Email: Hao Wang - hw@upcl.univ-lyon1.fr; Jean-Pierre Boissel - jpb@upcl.univ-lyon1.fr; Patrice Nony* - pn@upcl.univ-lyon1.fr * Corresponding author Published: 17 February 2009 Received: 7 August 2008 Accepted: 17 February 2009 Emerging Themes in Epidemiology 2009, 6:1 doi:10.1186/1742-7622-6-1 This article is available from: /content/6/1/1 © 2009 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In medical practice, it is generally accepted that the effect model describing the relationship between baseline risk and risk under treatment is linear, i.e. relative risk is constant. Absolute benefit is then proportional to a patients baseline risk and the treatment is most effective among high-risk patients. Alternatively, the effect model becom