role of structural mri in alzheimers disease结构的mri在阿尔茨海默病中的作用.pdfVIP

Vemuri and Jack Jr Alzheimer’s Research Therapy 2010, 2:23 /content/2/4/23 R E V I E W Role of structural MRI in Alzheimer’s disease Prashanthi Vemuri* and Clif ord R Jack Jr biomarker data and is adapted and illustrated in Figure 1. Abstract Owing to the close relationship between neuro degenera- Atrophy measured on structural magnetic resonance tion and cognition (as illustrated in Figure 1), atrophy imaging (sMRI) is a powerful biomarker of the stage measured on structural magnetic resonance imaging and intensity of the neurodegenerative aspect of (sMRI) is a powerful AD biomarker. Alzheimer’s disease (AD) pathology. In this review, we sMRI measures brain morphometry and therefore can will discuss the role of sMRI as an AD biomarker by capture gray matter atrophy related to the loss of summarizing (a) the most commonly used methods to neurons, synapses, and dendritic de-arborization that extract information from sMRI images, (b) the dif erent occurs on a microscopic level in AD; white matter roles in which sMRI can be used as an AD biomarker, atrophy related to the loss of structural integrity of white and (c) comparisons of sMRI with other major AD matter tracts, presumably resulting from demyelination biomarkers. and dying back of axonal processes; and ex vacuo expansion of cerebrospinal fl uid (CSF) spaces