role of titanium surface topography and surface wettability on focal adhesion kinase mediated signaling in fibroblasts钛表面形貌和表面润湿性能在成纤维细胞粘着斑激酶介导的信号.pdfVIP

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role of titanium surface topography and surface wettability on focal adhesion kinase mediated signaling in fibroblasts钛表面形貌和表面润湿性能在成纤维细胞粘着斑激酶介导的信号.pdf

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role of titanium surface topography and surface wettability on focal adhesion kinase mediated signaling in fibroblasts钛表面形貌和表面润湿性能在成纤维细胞粘着斑激酶介导的信号

Materials 2011, 4, 893-907; doi:10.3390/ma4050893 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Role of Titanium Surface Topography and Surface Wettability on Focal Adhesion Kinase Mediated Signaling in Fibroblasts Christine J. Oates 1, Weiyan Wen 2 and Douglas W. Hamilton 1,2,* 1 Graduate Program of Biomedical Engineering, The University of Western Ontario, London, N6A 5B9 Ontario, Canada; E-Mail: coates@uwo.ca (C.J.O.) 2 Division of Oral Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada; E-Mail: wwen@uwo.ca (W.W.) * Author to whom correspondence should be addressed; E-Mail: dhamil2@uwo.ca; Tel.: +1-519-661-2111 Ext. 81594; Fax: +1-519-850-2459. Received: 8 April 2011; in revised form: 22 April 2011 / Accepted: 5 May 2011/ Published: 9 May 2011 Abstract: Changes of titanium surface roughness and surface free energy may influence protein absorption that increases cell differentiation through activation of focal adhesion kinase related pathways. However, the influence of titanium surface roughness and hydrophilicity on fibroblast behavior is not well understood. The aim of this study was to investigate the influence of topography and hydrophilicity on fibroblast attachment, spreading, morphology, intracellular signaling, proliferation, and collagen I mRNA levels. Using a cellular FAK knockout (FAK−/−) model and wild-type (WT) controls, we also investigat