原创力文档role of toll-like receptor (tlr) 2 in experimental bacillus cereus endophthalmitistoll样受体(tlr)2在眼内炎实验蜡样芽胞杆菌.pdfVIP
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role of toll-like receptor (tlr) 2 in experimental bacillus cereus endophthalmitistoll样受体(tlr)2在眼内炎实验蜡样芽胞杆菌
Role of Toll-Like Receptor (TLR) 2 in Experimental
Bacillus cereus Endophthalmitis
1 2 1,2,3
Billy D. Novosad , Roger A. Astley , Michelle C. Callegan *
1 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 2 Department of
Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 3 Dean A. McGee Eye Institute, Oklahoma City,
Oklahoma, United States of America
Abstract
Bacillus cereus causes a uniquely rapid and blinding intraocular infection, endophthalmitis. B. cereus replicates in the eye,
synthesizes numerous toxins, and incites explosive intraocular inflammation. The mechanisms involved in the rapid and
explosive intraocular immune response have not been addressed. Because Toll-like receptors (TLRs) are integral to the
initial recognition of organisms during infection, we hypothesized that the uniquely explosive immune response observed
during B. cereus endophthalmitis is directly influenced by the presence of TLR2, a known Gram-positive pathogen
recognition receptor. To address this hypothesis, we compared the courses of experimental B. cereus endophthalmitis in
wild type C57BL/6J mice to that of age-matched homozygous TLR2-/- mice. Output parameters included analysis of
bacterial growth, inflammatory cell (PMN) infiltration, cytokine/chemokine kinetics, retinal function testing, and histology,
with N$4 eyes/assay/time point/mouse strain. B. cereus grew at similar rates to108 CFU/eye by 12 h, regardless of the
mouse strain. Retinal function was preserved to a greater degree in infected TLR2-/- eyes compared to that of i
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