same modulation but different starting points performance modulates age differences in inferior frontal cortex activity during word-retrieval调制相同但不同起点性能调节在单词retrieval劣质额叶皮层活动的年龄差异.pdfVIP

Same Modulation but Different Starting Points: Performance Modulates Age Differences in Inferior Frontal Cortex Activity during Word-Retrieval 1,2 3 4 4,5 2 Marcus Meinzer *, Tobias Flaisch , Lauren Seeds , Stacy Harnish , Daria Antonenko , Veronica 2 2 1,4 Witte , Robert Lindenberg , Bruce Crosson 1 Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America, 2 Department of Neurology, Center for Stroke ¨ Research Berlin and Cluster of Excellence NeuroCure, Charite Universitatsmedizin, Berlin, Germany, 3 Department of Psychology, University of Konstanz, Konstanz, Germany, 4 Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, Florida, United States of America, 5 Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Florida, United States of America Abstract The neural basis of word-retrieval deficits in normal aging has rarely been assessed and the few previous functional imaging studies found enhanced activity in right prefrontal areas in healthy older compared to younger adults. However, more pronounced right prefrontal recruitment has primarily been observed during challenging task conditions. Moreover, increased task difficulty may result in enhanced activity in the ventral inferior frontal gyrus (vIFG) bilaterally in younger participants as well. Thus, the question arises whether increased activity in older participants represents an age-related ph