scaffold sheet design strategy for soft tissue engineering软组织工程脚手架板设计策略.pdfVIP

Materials 2010, 3, 1375-1389; doi:10.3390/ma3021375 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Scaffold Sheet Design Strategy for Soft Tissue Engineering † Richard T. Tran, Paul Thevenot, Yi Zhang, Dipendra Gyawali, Liping Tang and Jian Yang * Department of Bioengineering, University of Texas at Arlington, 501 West First Street, Arlington, TX 76019, USA; E-Mails: mrtran@ (R.T.); pthevenot@ (P.T.); zhangy (Y.Z.); dipendra1411@ (D.G.); ltang@ (L.T) † Joint Biomedical Engineering Program between the University of Texas at Arlington and University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. * Author to whom correspondence should be addressed: E-Mail: jianyang@ (J.Y.); Tel.: 817-272-0562; Fax: 817-272-2251. Received: 30 January 2010 / Accepted: 22 February 2010 / Published: 24 February 2010 Abstract: Creating heterogeneous tissue constructs with an even cell distribution and robust mechanical strength remain important challenges to the success of in vivo tissue engineering. To address these issues, we are developing a scaffold sheet tissue engineering strategy consisting of thin (~200 μm), strong, elastic, and porous crosslinked urethane- doped polyester (CUPE) scaffold sheets that are bonded together chemically or through cell culture. Suture retention of the tissue constructs (four sheets) fabricated by the scaffold sheet tissue engineering strategy is close to the surgical requirement (1.8 N)