scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system清除能力的海洋类胡萝卜素对活性氧和氮物种membrane-mimicking系统.pdfVIP

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scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system清除能力的海洋类胡萝卜素对活性氧和氮物种membrane-mimicking系统.pdf

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scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system清除能力的海洋类胡萝卜素对活性氧和氮物种membrane-mimicking系统

Mar. Drugs 2012, 10, 1784-1798; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Scavenging Capacity of Marine Carotenoids against Reactive Oxygen and Nitrogen Species in a Membrane-Mimicking System Eliseu Rodrigues, Lilian R. B. Mariutti and Adriana Z. Mercadante * Department of Food Science, Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80, CEP 13083-862, Campinas, São Paulo 13083-970, Brazil; E-Mails: eliquimica2007@ (E.R.); lilianmariutti@ (L.R.B.M.) * Author to whom correspondence should be addressed; E-Mail: azm@fea.unicamp.br; Tel.: +55-19 Fax: +55-19 Received: 5 May 2012; in revised form: 7 July 2012 / Accepted: 25 July 2012 / Published: 20 August 2012 Abstract: Carotenoid intake has been associated with the decrease of the incidence of some chronic diseases by minimizing the in vivo oxidative damages induced by reactive oxygen (ROS) and nitrogen species (RNS). The carotenoids are well-known singlet oxygen quenchers; however, their capacity to scavenge other reactive species, such as peroxyl • • radical (ROO ), hydroxyl radical (HO ), hypochlorous acid (HOCl) and anion peroxynitrite − (ONOO ), still needs to be more extensively studied, especially using membrane-mimicking systems, such as liposomes. Moreover, the identification of carotenoids possessing high ant