role of glycogen synthase kinase-3β in app hyperphosphorylation induced by nmda stimulation in cortical neurons糖原合酶的作用在应用hyperphosphorylation kinase-3βnmda刺激诱发的皮层神经元.pdfVIP

Pharmaceuticals 2010, 3, 42-58; doi:10.3390/ph3010042 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons 1 1 1 2 3 Cristina Ploia , Alessandra Sclip , Alessio Colombo , Mariaelena Repici , Fabrizio Gardoni , Monica Di Luca 3, Gianluigi Forloni 1, Xanthi Antoniou 1 and Tiziana Borsello 1,* 1 Istituto di ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy; E-Mails: cristina.ploia@marionegri.it (C.P.); alessandra.sclip@marionegri.it (A.S.); alessiovittorio.colombo@marionegri.it (A.C.); gianluigi.forloni@marionegri.it (G.F.); xanthi.antoniou@marionegri.it (X.A.) 2 UMR 7102 Neurobiologie des Processus Adaptatifs, Universite P. et M. Curie, 9 quai St Bernard, 75005, Paris, France; E-Mail: mr200@le.ac.uk (M.R.) 3 Dipartimento Scienze Farmacologiche, Università degli Studi di Milano, Via Balzaretti, 9, 20133 Milano, Italy; E-Mail: fabrizio.gardoni@unimi.it (F.G.); monica.diluca@unimi.it (M.D.L.) * Author to whom correspondence should be addressed; E-Mail: tiziana.borsello@marionegri.it; Tel.: +39-0239014592; Fax: +39-02-3546277. Received: 23 October 2009; in revised form: 3 December 2009 / Accepted: 5 January 2010 / Published: 7 January 2010 Abstract: The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (