role of gene methylation in antitumor immune response implication for tumor progression基因甲基化在抗肿瘤免疫反应肿瘤恶化的影响.pdfVIP

下载本文档

2
0
约7.72万字
约 19页
2017-09-11 发布于上海
举报
版权申诉

role of gene methylation in antitumor immune response implication for tumor progression基因甲基化在抗肿瘤免疫反应肿瘤恶化的影响.pdf

1、本文档共19页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

role of gene methylation in antitumor immune response implication for tumor progression基因甲基化在抗肿瘤免疫反应肿瘤恶化的影响

Cancers 2011, 3, 1672-1690; doi:10.3390/cancers3021672 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression Alfonso Serrano 1, Isabel Castro-Vega 1 and Maximino Redondo 2,* 1 Department of Immunology, Hospital Clinico Universitario, Campus Universitario Teatinos S/N, 29010 Malaga, Spain 2 Department of Biochemistry, CIBER ESP, Hospital Costa del Sol, Marbella, Málaga, Carretera de Cadiz km 187, 29603, Spain * Author to whom correspondence should be addressed; E-Mail: mredondo@hcs.es. Received: 22 December 2010; in revised form: 9 March 2011 / Accepted: 24 March 2011 / Published: 29 March 2011 Abstract: Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor- associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defect