scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health科学证据和理由开发姜黄素和白藜芦醇nutraceutricals关节健康.pdfVIP

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scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health科学证据和理由开发姜黄素和白藜芦醇nutraceutricals关节健康.pdf

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scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health科学证据和理由开发姜黄素和白藜芦醇nutraceutricals关节健康

Int. J. Mol. Sci. 2012, 13, 4202-4232; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health Ali Mobasheri 1,*, Yves Henrotin 2, Hans-Konrad Biesalski 3 and Mehdi Shakibaei 4 1 Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington, LE12 5RD, UK 2 Bone and Cartilage Research Unit, Institute of Pathology, University of Liège, Sart-Tilman, 4000 Liège, Belgium; E-Mail: yhenrotin@ulg.ac.be 3 Department of Biological Chemistry and Nutrition, University of Hohenheim, D-70593 Stuttgart, Germany; E-Mail: Hans-K.Biesalski@uni-hohenheim.de 4 Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany; E-Mail: mehdi.shakibaei@med.uni-muenchen.de * Author to whom correspondence should be addressed; E-Mail: ali.mobasheri@nottingham.ac.uk; Tel.: +44-115-951-6449; Fax: +44-115-951-6440. Received: 27 February 2012; in revised form: 12 March 2012 / Accepted: 19 March 2012 / Published: 30 March 2012 Abstract: Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cy