原创力文档scrapie agent (strain 263k) can transmit disease via the oral route after persistence in soil over years痒病代理(菌株263 k)可以通过口服途径传播疾病后土壤中持久性多年.pdfVIP
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scrapie agent (strain 263k) can transmit disease via the oral route after persistence in soil over years痒病代理(菌株263 k)可以通过口服途径传播疾病后土壤中持久性多年
Scrapie Agent (Strain 263K) Can Transmit Disease via the
Oral Route after Persistence in Soil over Years
1. 2. 3. 3 1 2 4
Bjoern Seidel *, Achim Thomzig , Anne Buschmann , Martin H. Groschup , Rainer Peters , Michael Beekes , Konstantin Terytze
1 Fraunhofer Institute for Molecular Biology und Applied Ecology (IME), Schmallenberg, Germany, 2 P24 -Transmissible Spongiform Encephalopathies,
Robert Koch-Institut, Berlin, Germany, 3 Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Insel Riems, Germany,
4 German Federal Environmental Agency (Umweltbundesamt, UBA), Dessau, Germany
The persistence of infectious biomolecules in soil constitutes a substantial challenge. This holds particularly true with respect
to prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as scrapie, bovine spongiform
encephalopathy (BSE), or chronic wasting disease (CWD). Various studies have indicated that prions are able to persist in soil
for years without losing their pathogenic activity. Dissemination of prions into the environment can occur from several
sources, e.g., infectious placenta or amniotic fluid of sheep. Furthermore, environmental contamination by saliva, excrements
or non-sterilized agricultural organic fertilizer is conceivable. Natural transmission of scrapie in the field seems to occur via the
alimentary tract in the majority of cases, and scrapie-free sheep flocks can become infected on pastures where outbreaks of
scrapie had been observed before. These findings point to a sustained contagion in the environment, and notably the soil. By
using outdoor lysimeters, we simulated a contamination of standard soil with hamster-adapted 263K scrapie prions, and
analyzed the presence and
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