screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system检查步进部队的关节炎大鼠模型使用一种新型镇痛仪和数据采集系统.pdfVIP

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screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system检查步进部队的关节炎大鼠模型使用一种新型镇痛仪和数据采集系统.pdf

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screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system检查步进部队的关节炎大鼠模型使用一种新型镇痛仪和数据采集系统

Sensors 2012, 12, 9603-9612; doi:10.3390/s120709603 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Screening of Stepping Forces in an Arthritic Rat Model Using a Novel Analgesic Meter and Data Acquisition System Mun Fei Yam 1,*, Mariam Ahmad 1, Lip Yee Por 2, Lee Fung Ang 1, Rusliza Basir 3 and 1 Mohd. Zaini Asmawi 1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia; E-Mails: mariam@usm.my (M.A.); ang.leef@ (L.F.A.); amzaini@usm.my (M.Z.A.) 2 Faculty of Computer Science and Information Technology, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: porlip@.my 3 Unit of Pharmacology, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia; E-Mail: rusliza@.my * Author to whom correspondence should be addressed; E-Mail: yammunfei@; Tel.: +604-653-3888 (ext. 2162); Fax: +604-657-0017. Received: 15 June 2012; in revised form: 5 July 2012 / Accepted: 5 July 2012 / Published: 16 July 2012 Abstract: The stepping forces of normal and Freund Complete Adjuvant (FCA)-induced arthritic rats were studied in vivo using a proposed novel analgesic meter. An infrared charge-coupled device (CCD) camera and a data acquisition system were incorporated into the analgesic meter to determine and measure the weight of loads on the right hind paw before and after induction of arthritis by FCA injection into the paw cavity. FCA injection resulted in a significant re