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screening technologies for target identification in pancreatic cancer筛选目标识别技术在胰腺癌
Cancers 2011, 3, 79-90; doi:10.3390/cancers3010079
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
Screening Technologies for Target Identification in
Pancreatic Cancer
Patrick Michl *, Stefanie Ripka, Thomas Gress and Malte Buchholz
Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University
Marburg, Baldinger Strasse, D-35043 Marburg, Germany; E-Mail: gastro@med.uni-marburg.de (T.G.)
* Author to whom correspondence should be addressed; E-Mail: michlp@med.uni-marburg.de;
Tel.: +49 6421 586 6460; Fax: +49 6421 586 8922.
Received: 23 November 2010; in revised form: 21 December 2010 / Accepted: 23 December 2010 /
Published: 29 December 2010
Abstract: Pancreatic cancer exhibits an extraordinarily high level of resistance to almost
any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification
of novel therapeutic targets is urgently required. High-throughput screens have emerged as
an important tool to identify putative targets for diagnosis and therapy in an unbiased
manner. More than a decade ago, microarray technology was introduced to identify
differentially expressed genes in pancreatic cancer as compared to normal pancreas,
chronic pancreatitis and other cancer types located in close proximity to the pancreas. In
addition, proteomic screens have facilitated the identification of differentially secreted
proteins in body fluids of pancreatic cancer pa
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