sdf1-induced antagonism of axonal repulsion requires multiple g-protein coupled signaling components that work in parallelsdf1-induced拮抗轴突排斥需要多个g蛋白耦合信号并行工作的组件.pdfVIP

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sdf1-induced antagonism of axonal repulsion requires multiple g-protein coupled signaling components that work in parallelsdf1-induced拮抗轴突排斥需要多个g蛋白耦合信号并行工作的组件.pdf

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sdf1-induced antagonism of axonal repulsion requires multiple g-protein coupled signaling components that work in parallelsdf1-induced拮抗轴突排斥需要多个g蛋白耦合信号并行工作的组件

SDF1-Induced Antagonism of Axonal Repulsion Requires Multiple G-Protein Coupled Signaling Components That Work in Parallel 1 2 E. Naomi Twery , Jonathan A. Raper * 1 Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2 Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America Abstract SDF1 reduces the responsiveness of axonal growth cones to repellent guidance cues in a pertussis-toxin-sensitive, cAMP- dependent manner. Here, we show that SDF1’s antirepellent effect can be blocked in embryonic chick dorsal root ganglia (DRGs) by expression of peptides or proteins inhibiting either Ga , Ga , or Gbc. SDF1 antirepellent activity is also blocked by i q pharmacological inhibition of PLC, a common effector protein for Gaq. We also show that SDF1 antirepellent activity can be mimicked by overexpression of constitutively active Ga , Ga , or Ga . These results suggest a model in which multiple G i q s protein components cooperate to produce the cAMP levels required for SDF1 antirepellent activity. Citation: Twery EN, Raper JA (2011) SDF1-Induced Antagonism of Axonal Repulsion Requires Multiple G-Protein Coupled Signaling Components That Work in Parallel. PLoS ONE 6(4): e18896. doi:10.1371/journal.pone.0018896 Editor: Edward Giniger, National Institutes of Health (NIH), United States of America Received December 22, 2010; Accepted March 24, 2011; Published April 27, 2011 Copyright: 2011 Twery, Raper. This is an open-access article distributed under the terms of the Creative Commons Attribution Lice