rs1004819 is the main disease-associated il23r variant in german crohns disease patients combined analysis of il23r, card15, and octn12 variantsrs1004819是主要的变异il23r变体在德国克罗恩病病人il23r相结合的分析方法,card15,octn12变体.pdfVIP
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rs1004819 is the main disease-associated il23r variant in german crohns disease patients combined analysis of il23r, card15, and octn12 variantsrs1004819是主要的变异il23r变体在德国克罗恩病病人il23r相结合的分析方法,card15,octn12变体
rs1004819 Is the Main Disease-Associated IL23R Variant
in German Crohn’s Disease Patients: Combined Analysis
of IL23R, CARD15, and OCTN1/2 Variants
¨ 1,2 1 1,2 1 ¨ ¨ 1 1 2 2
Jurgen Glas , Julia Seiderer , Martin Wetzke , Astrid Konrad , Helga-Paula Torok , Silke Schmechel , Laurian Tonenchi , Christine Grassl ,
1 1 2 4 5 ¨ 5 6 3
Julia Dambacher , Simone Pfennig , Kerstin Maier , Thomas Griga , Wolfram Klein , Jorg T. Epplen , Uwe Schiemann , Christian Folwaczny ,
7 ¨ 1 ¨ 1 ¨ 8 2 3 1
Peter Lohse , Burkhard Goke , Thomas Ochsenkuhn , Bertram Muller-Myhsok , Matthias Folwaczny , Thomas Mussack , Stephan Brand *
1 Department of Medicine II - Grosshadern, University of Munich, Munich, Germany, 2 Clinic for Preventive Dentistry and Parodontology, University of
Munich, Munich, Germany, 3 Department of Surgery, University of Munich, Munich, Germany, 4 Department of Internal Medicine,
Knappschaftskrankenhaus Dortmund, Dortmund, Germany, 5 Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany,
6 Department of General Internal Medicine, Inselspital Bern, Bern, Switzerland, 7 Institute of Clinical Chemistry, Grosshadern, University of Munich,
Munich, Germany, 8 Max Planck Institute of Psychiatry, Munich, Germany
Background. The IL23R gene has been identified as a susceptibility gene for inflammatory bowel disease (IBD) in the North
American population. The aim of our study was to test this association in a large G
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