seco-briarellinone and briarellin s, two new eunicellin-based diterpenoids from the panamanian octocoral briareum asbestinumseco-briarellinone和briarellin年代,两个新的eunicellin-based二萜的巴拿马octocoral briareum asbestinum.pdfVIP

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seco-briarellinone and briarellin s, two new eunicellin-based diterpenoids from the panamanian octocoral briareum asbestinumseco-briarellinone和briarellin年代,两个新的eunicellin-based二萜的巴拿马octocoral briareum asbestinum.pdf

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seco-briarellinone and briarellin s, two new eunicellin-based diterpenoids from the panamanian octocoral briareum asbestinumseco-briarellinone和briarellin年代,两个新的eunicellin-based二萜的巴拿马octocoral briareum asbestinum

Mar. Drugs 2012, 10, 2608-2617; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum José Félix Gómez-Reyes 1,2, Ana Salazar 1, Héctor M. Guzmán 3, Yisett González 4, Patricia L. Fernández 4, Armando Ariza-Castolo 2 and Marcelino Gutiérrez 1,* 1 Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama; E-Mails: jfgomez@cinvestav.mx (J.F.G.-R.); ansal2181@ (A.S.) 2 Department of Chemistry, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), P.O. Box 14-740, 07000, F.D., Mexico; E-Mail: aariza@cinvestav.mx 3 Smithsonian Tropical Research Institute, Balboa, Ancon, P.O. Box 0843-03092, Panama; E-Mail: guzmanh@ 4 Center for Molecular and Cellular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama; E-Mails: yisettgonzalez@ (Y.G.); patryllanes@ (P.L.F.) * Author to whom correspondence should be addressed; E-Mail: mgutierrez@.pa; Tel.: +507-517-0732; Fax: +507-517-0701. Received: 20 August 2012; in revised form: 26 September 2012 / Accepted: 22 October 2012 / Published: 21 November 2012 Abstract: Two new eunicellin-based diterpenes, seco-briarellinone (1) and briarellin S (2), and a known seco-asbestinin (3) have been isolated from the metha