原创力文档salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of ratssalsolinol促进glutamatergic传播后腹侧被盖区多巴胺神经元的老鼠.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of ratssalsolinol促进glutamatergic传播后腹侧被盖区多巴胺神经元的老鼠
Salsolinol Facilitates Glutamatergic Transmission to
Dopamine Neurons in the Posterior Ventral Tegmental
Area of Rats
Guiqin Xie, Jiang-Hong Ye*
Department of Anesthesiology, Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey,
United States of America
Abstract
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties
that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated. We have reported previously
that salsolinol stimulates dopamine neurons in the posterior ventral tegmental area (p-VTA) partly by reducing inhibitory
GABAergic transmission, and that ethanol increases glutamatergic transmission to VTA-dopamine neurons via the activation of
dopamine D receptors (D Rs). In this study, we tested the hypothesis that salsolinol stimulates dopamine neurons involving
1 1
activation of D1Rs. By using whole-cell recordings on p-VTA-dopamine neurons in acute brain slices of rats, we found that
salsolinol-induced increase in spike frequency of dopamine neurons was substantially attenuated by DL-2-amino-5-
phosphono-valeric acid and 6, 7-dinitroquinoxaline-2, 3-dione, the antagonists of glutamatergic N-Methyl-D-aspartic acid and
a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Moreover, salsolinol increased the amplitude of evoked
excitatory postsynaptic currents (EPSCs) and the frequency but not the amplitude of spontaneous EPSCs. Additionally,
SKF83566, a D1R antagonist attenuated the salsolinol-induced facilitation of EPSCs and of spontaneous firing of dopamine
neurons. Our data reveal that salsolinol enhances glutamatergic transmission onto dopamine neurons via activation of D1Rs
您可能关注的文档
- rituximab for children with immune thrombocytopenia a systematic review美罗华对儿童免疫血小板减少系统回顾.pdf
- risk stratification of early admission to the intensive care unit of patients with no major criteria of severe community-acquired pneumonia development of an international prediction rule危险分层的早期进入重症监护室的病人,没有重症社区获得性肺炎的主要标准国际预测规则的发展.pdf
- risk perception and occupational accidents a study of gas station workers in southern brazil感知风险和职业事故研究加油站工人在巴西南部.pdf
- risks of using antifouling biocides in aquaculture在水产养殖中使用防污农药的风险.pdf
- river dolphins can act as population trend indicators in degraded freshwater systems河海豚可以作为人口趋势指标退化的淡水系统.pdf
- rituximab therapy reduces activated b cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis depletion of memory b cells correlates with clinical response美罗华治疗降低激活b细胞在类风湿性关节炎患者的外周血和骨髓枯竭的记忆b细胞与临床反应.pdf
- rna and dna bacteriophages as molecular diagnosis controls in clinical virology a comprehensive study of more than 45,000 routine pcr testsrna和dna噬菌体控制分子诊断在临床病毒学的全面研究超过45000常规pcr测试.pdf
- rituximab therapy reduces organ-specific t cell responses and ameliorates experimental autoimmune encephalomyelitis美罗华治疗实验性自身免疫性脑脊髓炎减少瀑特异性t细胞的反应和改善.pdf
- rna accessibility in cubic timerna在立方时间可访问性.pdf
- rna detection in live bacterial cells using fluorescent protein complementation triggered by interaction of two rna aptamers with two rna-binding peptidesrna检测使用荧光蛋白在活细菌细胞引发的互补互动的两个rna寡核苷酸适配子与两个rna结合肽.pdf
- salp15 binding to dc-sign inhibits cytokine expression by impairing both nucleosome remodeling and mrna stabilizationsalp15绑定dc-sign抑制细胞因子的表达通过损害核小体重塑和mrna稳定.pdf
- salt stress induced variation in dna methylation pattern and its influence on gene expression in contrasting rice genotypes盐胁迫诱导dna甲基化模式的变化及其对基因表达的影响在不同水稻基因型.pdf
- salmonella isolated from animals and feed production in sweden between 1993 and 1997沙门氏菌分离出动物和饲料生产在瑞典在1993年和1997年之间.pdf
- salt tolerance in solanum pennellii antioxidant response and related qtl盐耐受茄属植物pennellii抗氧化反应和相关的qtl.pdf
- sam domain-based protein oligomerization observed by live-cell fluorescence fluctuation spectroscopy山姆域的蛋白寡聚化live-cell观察到荧光光谱波动.pdf
- samarium (iii) selective membrane sensor based on tin (iv) boratophosphate钐(iii)选择性膜传感器基于锡(iv)boratophosphate.pdf
- same modulation but different starting points performance modulates age differences in inferior frontal cortex activity during word-retrieval调制相同但不同起点性能调节在单词retrieval劣质额叶皮层活动的年龄差异.pdf
- sample preparation and liquid chromatography-tandem mass spectrometry for multiple steroids in mammalian and avian circulation样品制备和液体chromatography-tandem质谱为多个类固醇在哺乳动物和鸟类的血液循环.pdf
- salmonella enterica serovar typhimurium adhesion and cytotoxicity during epithelial cell stress is reduced by lactobacillus rhamnosus gg鼠伤寒沙门氏菌血清型粘附在上皮细胞和细胞毒性压力减少乳杆菌gg.pdf
- salmonella in sheep in iceland沙门氏菌在冰岛的羊.pdf
文档评论（0）