segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population种族隔离的监管多态性对臀中肌的影响转录组纯种猪群.pdfVIP
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segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population种族隔离的监管多态性对臀中肌的影响转录组纯种猪群
Segregation of Regulatory Polymorphisms with Effects
on the Gluteus Medius Transcriptome in a Purebred Pig
Population
´ 1 1 2 ´ 2 3
Angela Canovas , Ramona N. Pena *, David Gallardo , Oscar Ramırez , Marcel Amills ,
Raquel Quintanilla1*
` ` ` `
1 IRTA, Genetica i Millora Animal, Lleida, Spain, 2 Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra,
` ` `
Barcelona, Spain, 3 Departament de Genetica Animal, Centre de Recerca en Agrigenomica (CRAG), Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
Abstract
Background: The main goal of the present study was to analyse the genetic architecture of mRNA expression in muscle, a
tissue with an outmost economic importance for pig breeders. Previous studies have used F2 crosses to detect porcine
expression QTL (eQTL), so they contributed with data that mostly represents the between-breed component of eQTL
variation. Herewith, we have analysed eQTL segregation in an outbred Duroc population using two groups of animals with
divergent fatness profiles. This approach is particularly suitable to analyse the within-breed component of eQTL variation,
with a special emphasis on loci involved in lipid metabolism.
Methodology/Principal Findings: GeneChip Porcine Genome arrays (Affyme
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