self-assembly of protein monolayers engineered for improved monoclonal immunoglobulin g binding自组装单层的蛋白质工程改善单克隆免疫球蛋白g绑定.pdfVIP
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self-assembly of protein monolayers engineered for improved monoclonal immunoglobulin g binding自组装单层的蛋白质工程改善单克隆免疫球蛋白g绑定
Int. J. Mol. Sci. 2011, 12, 5157-5167; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Self-Assembly of Protein Monolayers Engineered for Improved
Monoclonal Immunoglobulin G Binding
1,† 2 2 3,†
Anton P. Le Brun , Deepan S. H. Shah , Dale Athey , Stephen A. Holt and
Jeremy H. Lakey 1,*
1 Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University,
Framlington Place, Newcastle upon Tyne, NE2 4HH, UK; E-Mail: abn@.au
2 Orla Protein Technologies Ltd, Biosciences Centre, International Centre for Life, Times Square,
Newcastle upon Tyne, NE1 4EP, UK; E-Mails: deepan.s.shah@;
proteins@
3 ISIS Neutron Facility, STFC Rutherford Appleton Laboratory, Harwell Science and Innovation
Campus, Didcot, Oxfordshire, OX11 0QX, UK; E-Mail: sph@.au
† Current address: Bragg Institute, Australian Nuclear Science and Technology Organisation,
Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.
* Author to whom correspondence should be addressed; E-Mail: j.h.lakey@ncl.ac.uk;
Fax: +44-191-222-7424.
Received: 4 July 2011; in revised form: 4 July 2011 / Accepted: 10 August 2011 /
Published: 15 August 2011
Abstract: Bacteria
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