serum screening with downs syndrome markers to predict pre-eclampsia and small for gestational age systematic review and meta-analysis血清与唐氏综合征筛查标志物预测先兆子痫和小胎龄的系统回顾和荟萃分析.pdfVIP

BMC Pregnancy and Childbirth BioMed Central Research article Open Access Serum screening with Downs syndrome markers to predict pre-eclampsia and small for gestational age: Systematic review and meta-analysis Rachel K Morris*, Jeltsje S Cnossen, Marloes Langejans, Stephen C Robson, Jos Kleijnen, Gerben ter Riet, Ben W Mol, Joris AM van der Post and Khalid S Khan Address: Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham Womens Hospital, Birmingham, B15 2TG, UK Email: Rachel K Morris* - r.k.morris@bham.ac.uk; Jeltsje S Cnossen - J.S.Cnossen@amc.uva.nl; Marloes Langejans - marloes_2000@; Stephen C Robson - s.c.robson@ncl.ac.uk; Jos Kleijnen - jos@; Gerben ter Riet - g.terriet@amc.nl; Ben W Mol - b.w.mol@amc.uva.nl; Joris AM van der Post - j.a.vanderpost@amc.nl; Khalid S Khan - k.s.khan@bham.ac.uk * Corresponding author Published: 4 August 2008 Received: 4 March 2008 Accepted: 4 August 2008 BMC Pregnancy and Childbirth 2008, 8:33 doi:10.1186/1471-2393-8-33 This article is available from: /1471-2393/8/33 © 2008 Morris et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Reliable antenatal identification of pre-eclampsia and small for gestational age is crucial to judicious allocation of monitoring resources and use of preventative treatment with the prospect of improving maternal/perinatal out