具时滞肿瘤免疫反应模型稳定性及hopf分支-bowenpublishing.pdfVIP

Feb. 2015, Volume 5, Issue 1, PP.8-13 Scientific Journal of Mathematics Research 具时滞肿瘤免疫反应模型稳定性及Hopf 分支* 1 2 3 丁倩 ，朱惠延 ，王海兰 南华大学数理学院，湖南省，衡阳市，421001 摘 要：本文研究了一类肿瘤免疫反应增长模型，考虑到免疫反应中T 细胞的活化过程会产生时滞，故建立了三维时滞微分 方程对肿瘤免疫反应动力学性质进行研究。通过线性系统特征方程根的分布情况，讨论了系统平衡点在无时滞情况下的局部 稳定性和正平衡点存在的条件，再重点研究了具有时滞的情形，得出了正平衡点的渐近稳定性及Hopf 分支的存在条件。 关键词：免疫反应；时滞；稳定性；Hopf 分支 Stability and Hopf Bifurcation for the Model of Tumor Immune Response with Time Delay 1 2 3 Qian Ding , Huiyan Zhu , Hailan Wang 1. School of Mathematics and Physics, University of South China, Hengyang, Hunan, China, 421001 Email: 1553139112@; 2zhuhuiyan@126.com Abstract: This paper deals with a model describing the interaction between tumor and immune cells. Considering the activation process and conversion of T-cells are not instantaneous but followed by some time lag, we established the three-dimensional delay differential equations to investigate dynamics of tumor immune response. By analyzing the distribution of characteristic equation root, we discussed the asymptotic stability of the equilibria of the system without delay, and studied the existence of positive equilibrium conditions. For the delay-induced model, we have drawn the conclusions that the system is asymptotic stability of positive equilibrium and the existence conditions of Hopf bifurcation. Keywords: Immune Response; Delay; Stability; Hopf Bifurcation 引言 生物治疗[1] 已成为手术、化疗、放疗之外的第四种肿瘤疗法。它主要着眼于调动机体自身的抗癌能力，通过 增强机体固有的抗癌机制来杀伤或抑制肿瘤细胞，以达到根治的目标，这种治疗策略是合理的，因此近年来日益受 到重视。肿瘤免疫[2-3]过程是肿瘤细胞的特异性蛋白激发免疫系统释放免疫细胞、分子和颗粒对肿瘤细胞进行攻 击的过程。免疫细胞占相对主导地位，主要有T 淋巴细胞、B 淋巴细胞和自然杀伤细胞，本文主要考虑T 淋巴细胞。