analysing the origin of long-range interactions in proteins using lattice models在蛋白质分析的起源远程交互使用点阵模型.pdfVIP

BMC Structural Biology BioMed Central Research article Open Access Analysing the origin of long-range interactions in proteins using lattice models 1 2 1 Orly Noivirt-Brik , Ron Unger* and Amnon Horovitz* Address: 1Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel and 2The Mina Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel Email: Orly Noivirt-Brik - Orly.Noivirt@weizmann.ac.il; Ron Unger* - ron@biocom1.ls.biu.ac.il; Amnon Horovitz* - Amnon.Horovitz@weizmann.ac.il * Corresponding authors Published: 29 January 2009 Received: 18 November 2008 Accepted: 29 January 2009 BMC Structural Biology 2009, 9:4 doi:10.1186/1472-6807-9-4 This article is available from: /1472-6807/9/4 © 2009 Noivirt-Brik et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Long-range communication is very common in proteins but the physical basis of this phenomenon remains unclear. In order to gain insight into this problem, we decided to explore whether long-range interactions exist in lattice models of proteins. Lattice models of proteins have proven to capture some of the basic properties of real pro