single course of high dose dexamethasone is more effective than conventional prednisolone therapy in the treatment of primary newly diagnosed immune thrombocytopenia单一的高剂量地塞米松比传统强的松治疗更有效的治疗主要新诊断免疫血小板减少.pdfVIP

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single course of high dose dexamethasone is more effective than conventional prednisolone therapy in the treatment of primary newly diagnosed immune thrombocytopenia单一的高剂量地塞米松比传统强的松治疗更有效的治疗主要新诊断免疫血小板减少.pdf

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single course of high dose dexamethasone is more effective than conventional prednisolone therapy in the treatment of primary newly diagnosed immune thrombocytopenia单一的高剂量地塞米松比传统强的松治疗更有效的治疗主要新诊断免疫血小板减少

Mashhadi et al. DARU Journal of Pharmaceutical Sciences 2012, 20:7 /content/20/1/7 RESEARCH ARTICLE Open Access Single course of high dose dexamethasone is more effective than conventional prednisolone therapy in the treatment of primary newly diagnosed immune thrombocytopenia 1* 1 2 1,3 Mohammad Ali Mashhadi , Mahmoud Ali Kaykhaei , Zahra Sepehri and Ebrahim Miri-Moghaddam Abstract Introduction: Immune thrombocytopenia (ITP) is an immune disorder commonly presents as isolated thrombocytopenia. Generally corticosteroids are the main treatment of ITP. This study was designed to evaluate effectiveness of high dose dexamethasone comparing conventional corticosteroid therapy in the treatment of ITP. Materials and methods: In a randomized prospective study, sixty adult patients with newly diagnosed primary symptomatic ITP (Platelet count 20,000) were evaluated. Patients divided into two groups. In group A, thirty patients (mean age of 24.9 years) received Dexamethasone 40 mg/IV/daily for four days (10 mg/q6h); and then Prednisolone 1 mg/kg/day/PO with rapid tapering of prednisolone (10 mg/week). From the other hand, in group B, thirty patients (mean age of 27.2 years) were treated with Prednisolone 1 mg/kg/day/PO for four weeks, then the drug tapered weekly. Results: All the patients in group A showed favorable response within the first seven days, 27 cases presented complete response (CR) and three cases revealed response (R). In group B, 11 cases had CR, 13 cases showed R and six cases had No response (NR). After three months, rates of CR were 80% and 23.3% in group A and B; respectively. Responses were 16.7% and 33.3%, NRs were 6.6% and 43.3% in group A and B; respectively (P 0.0001)