原创力文档soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion a prospective cohort study可溶性髓cells-1触发受体是表示在非感染性炎症后创伤性肺挫伤前瞻性群组研究.pdfVIP
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soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion a prospective cohort study可溶性髓cells-1触发受体是表示在非感染性炎症后创伤性肺挫伤前瞻性群组研究
Bingold et al. Critical Care 2011, 15:R115
/content/15/2/R115
RESEARCH Open Access
Soluble triggering receptor on myeloid cells-1 is
expressed in the course of non-infectious
inflammation after traumatic lung contusion:
a prospective cohort study
1* 1 1 2 2 1
Tobias M Bingold , Barbara Pullmann , Sven Sartorius , Emanuel V Geiger , Ingo Marzi , Kai Zacharowski ,
Heimo Wissing3† and Bertram Scheller1†
Abstract
Introduction: The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during
bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following
traumatic lung contusion.
Methods: In a study population of 45 adult patients with multiple trauma and lung contusion, we obtained
bronchoalveolar lavage (BAL) (blind suctioning of 20 ml NaCl (0.9%) via jet catheter) and collected blood samples
at two time points (16 hours and 40 hours) after trauma. Post hoc patients were assigned to one of four groups
radiologically classified according to the severity of lung contusion based on the initial chest tomography.
Concentration of soluble TREM-1 (sTREM-1) and bacterial growth were determined in the BAL. sTREM-1, IL-6, IL-10,
lipopolysaccharide binding protein, procalcitonin, C-reactive protein and leukocyte count were assessed in blood
samples. Pulmonary function was evaluated by the paO2/FiO2 ratio.
Results: Three patients were excluded due to positive bacterial growth in the initial BAL. In 42 patients the severity
of lung contusion correlated with the levels of sTREM-1 16 hours and 40 hours after trauma. sTREM-1 levels were
significantly (P 0.01) elevated in patients with severe contusion (2,184 pg/ml (620 to 4,000
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