原创力文档stability of mrnadna and dnadna duplexes affects mrna transcriptionmrnadna稳定和dnadna工器影响mrna转录.pdfVIP
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stability of mrnadna and dnadna duplexes affects mrna transcriptionmrnadna稳定和dnadna工器影响mrna转录
Stability of mRNA/DNA and DNA/DNA Duplexes Affects
mRNA Transcription
1 ¤a ¤b ¤c 1 1
Rayna I. Kraeva , Dragomir B. Krastev , Assen Roguev , Anna Ivanova , Marina N. Nedelcheva-Veleva , Stoyno S. Stoynov *
1Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the
transfer of genetic information and can modulate gene expression. However, the nucleotide sequence alone is insufficient in
explaining phenomena like intron-exon recognition during RNA processing. This raises the question whether nucleic acids are
endowed with other attributes that can contribute to their biological functions. In this work, we present a calculation of
thermodynamic stability of DNA/DNA and mRNA/DNA duplexes across the genomes of four species in the genus
Saccharomyces by nearest-neighbor method. The results show that coding regions are more thermodynamically stable than
introns, 39-untranslated regions and intergenic sequences. Furthermore, open reading frames have more stable sense mRNA/
DNA duplexes than the potential antisense duplexes, a property that can aid gene discovery. The lower stability of the DNA/
DNA and mRNA/DNA duplexes of 39-untranslated regions and the higher stability of genes correlates with increased mRNA
level. These results suggest that the thermodynamic stability of DNA/DNA and mRNA/DNA duplexes affects mRNA
transcription.
Citation: Kraeva RI, Krastev DB, Roguev A, Ivanova A, Nedelcheva-Veleva MN, et al (2007) Stability of mRNA/DNA and DNA/DNA Duplexes Affects
mRNA Transcription. PLoS ONE 2(3): e290. doi:10.1371/journal.pone.0000290
INTRODUCT
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