原创力文档strategies for the use of poly(adenosine diphosphate ribose) polymerase (parp) inhibitors in cancer therapy策略的使用保利(腺苷二磷酸核糖聚合酶(parp)抑制剂在癌症治疗.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
strategies for the use of poly(adenosine diphosphate ribose) polymerase (parp) inhibitors in cancer therapy策略的使用保利(腺苷二磷酸核糖聚合酶(parp)抑制剂在癌症治疗
Biomolecules 2012, 2, 635-649; doi:10.3390/biom2040635
OPEN ACCESS
biomolecules
ISSN 2218-273X
/journal/biomolecules/
Review
Strategies for the Use of Poly(adenosine diphosphate ribose)
Polymerase (PARP) Inhibitors in Cancer Therapy
Cecilia E. Ström and Thomas Helleday *
Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of
Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden;
E-Mails: cecilia.strom@scilifelab.se (C.S.)
* Author to whom correspondence should be addressed; E-Mail: thomas.helleday@scilifelab.se;
Tel.: +46-852-480-000.
Received: 12 October 2012; in revised form: 29 November 2012 / Accepted: 9 December 2012 /
Published: 14 December 20 12
Abstract: Treatments with Poly(adenosine diphosphate ribose) polymerase (PARP)
inhibitors have offered patients carrying cancers with mutated BRCA1 or BRCA2 genes a
new and in many cases effective option for disease control. There is potentially a large
patient population that may also benefit from PARP inhibitor treatment, either in
monotherapy or in combination with chemotherapy. Here, we describe the multifaceted role
of PARP inhibitors and discuss which treatment options could potentially be useful to gain
disease control without potentiating side effects.
Keywords: DNA repair; poly(ADP-ribose) polymerase; synthetic lethality; cancer
1. Introduction
Nearly 50 years ago, the first member of the large ADP-ribosyltransferase superfamily of prote
您可能关注的文档
- spatial pattern of standing timber value across the brazilian amazon空间格局的建筑用材价值在巴西亚马逊河.pdf
- spatial orientation in japanese quails (coturnix coturnix japonica)空间定位在日本鹌鹑(coturnix coturnix粳稻).pdf
- spatial heterogeneity in resource distribution promotes facultative sociality in two trans-saharan migratory birds资源分布的空间异质性促进兼性社会性撒哈拉沙漠候鸟在两个.pdf
- spatial patterns in herbivory on a coral reef are influenced by structural complexity but not by algal traits空间模式在食草性珊瑚礁受到结构复杂性的影响但不是由藻类特征.pdf
- spatial heterogeneity of autoinducer regulation systemsautoinducer监管系统的空间异质性.pdf
- spatial patterns of aflatoxin levels in relation to ear-feeding insect damage in pre-harvest corn黄曲霉毒素水平的空间格局与ear-feeding虫害秋收之前的那次在玉米.pdf
- spatial forecast of landslides in three gorges based on spatial data mining的山体滑坡空间预测三峡基于空间数据挖掘.pdf
- spatial proximity and similarity of the epigenetic state of genome domains空间距离和相似性的基因组的表观遗传状态域.pdf
- spatial patterns of transcriptional activity in the chromosome of escherichia coli空间的转录活动模式在大肠杆菌的染色体.pdf
- spatial patterns of bovine corona virus and bovine respiratory syncytial virus in the swedish beef cattle population牛冠状病毒的空间模式和牛呼吸道合胞体病毒瑞典肉牛人口.pdf
- strategies to optimize analgesia and sedation策略优化镇痛和镇静.pdf
- strategy for adapting wine yeasts for bioethanol production战略适应生物乙醇生产的葡萄酒酵母.pdf
- strategies for successful information technology adoption in small and medium-sized enterprises战略成功的信息技术在中小企业采用.pdf
- strategy for treating motor neuron diseases using a fusion protein of botulinum toxin binding domain and streptavidin for viral vector access work in progress治疗运动神经元疾病的策略使用肉毒杆菌毒素的融合蛋白绑定域和链霉亲和素对病毒载体访问工作进展.pdf
- strategy of transcription regulation in the budding yeast出芽酵母转录调控的策略.pdf
- stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors the egfr fluorescence in situ hybridization assay分层治疗非小细胞肺癌病人的表皮生长因子受体抑制剂的表皮生长因子受体荧光原位杂交试验.pdf
- stratification, blinding and placebo effect in a randomized, double blind placebo-controlled clinical trial of gold bead implantation in dogs with hip dysplasia分层,致盲和安慰剂效应的随机、双盲安慰剂对照临床试验的黄金珠子植入犬髋关节发育不良.pdf
- strategy for encoding and comparison of gene expression signatures编码策略和比较基因表达的签名.pdf
- stream segregation in the perception of sinusoidally amplitude-modulated tones流隔离的感觉呈现正弦调幅音调.pdf
- strengthening health systems at facility-level feasibility of integrating antiretroviral therapy into primary health care services in lusaka, zambia加强卫生系统在设施水平整合的可行性在卢萨卡抗逆转录病毒疗法纳入初级卫生保健服务,赞比亚.pdf
文档评论（0）