supplementary oxygen for nonhypoxemic patients o2 much of a good thing补充氧气nonhypoxemic患者o2的一件好事.pdfVIP

Iscoe et al. Critical Care 2011, 15:305 /content/15/3/305 VIE WPOINT Supplementary oxygen for nonhypoxemic patients: O2 much of a good thing? 1 2 3 Steve Iscoe *, Richard Beasley and Joseph A Fisher theoretically increasing tissue oxygen delivery (DO2) Abstract assuming no reduction in tissue blood fl ow. However, Supplementary oxygen is routinely administered to oxygen causes constriction of the coronary, cerebral, patients, even those with adequate oxygen saturations, renal and other key vasculatures – and if regional per- in the belief that it increases oxygen delivery. But fusion decreases concomitantly with blood hyperoxyge- oxygen delivery depends not just on arterial oxygen nation, one would have a seemingly paradoxical situation content but also on perfusion. It is not widely in which the administration of oxygen may place tissues recognized that hyperoxia causes vasoconstriction, at increased risk of hypoxic stress. Any tissue damage in either directly or through hyperoxia-induced the course of oxygen administration would plausibly be hypocapnia. If perfusion decreases more than arterial attributed to the underlying disease process. Ascribing oxygen content increases during hyperoxia, then hypoxic damage to oxygen administration is counter- regional oxygen delivery decreases. This mechanism, intuitive and is difficult to accept withou