symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study在创伤后应激障碍症状的持久性和记忆表现基因x环境试验研究.pdfVIP
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symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study在创伤后应激障碍症状的持久性和记忆表现基因x环境试验研究
Behav. Sci. 2012, 2, 103-114; doi:10.3390/bs2020103
OPEN ACCESS
Behavioral
Sciences
ISSN 2076-328X
/journal/behavsci/
Aticle
Symptom Persistence and Memory Performance in
Posttraumatic Stress Disorder: A Gene X Environment
Pilot Study
Annie-Claude David 1,2, Geeta A. Thakur 2,3, Vivian Akerib 2, Jorge Armony 2,3,
Isabelle Rouleau 1 and Alain Brunet 2,3,*
1 Department of Psychology, Université du Québec à Montréal, Montreal H2X 1L7, Canada;
E-Mails: annieclaude.david@ (A.-C.D.); rouleau.isabelle@uqam.ca (I.R.)
2 Douglas Mental Health University Institute, Montreal H4H 1R2, Canada;
E-Mails: geeta.thakur@douglas.mcgill.ca (G.A.T.); vakerib@videotron.ca (V.A.);
jorge.armony@mcgill.ca (J.A.)
3 Department of Psychiatry, McGill University, Montreal H3A 0G4, Canada
* Author to whom correspondence should be addressed; E-Mail: alain.brunet@mcgill.ca;
Tel.: +1-514-761-6131 (ex 2375); Fax: +1-514-762-3049.
Received: 25 April 2012; in revised form: 24 May 2012 / Accepted: 24 May 2012 /
Published: 1 June 2012
Abstract: The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of
stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal
(HPA)-axis regulation. However, studies finding a genetic relationship between
posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish
between the development and persistence of PTSD, thereby limit
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