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symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study在创伤后应激障碍症状的持久性和记忆表现基因x环境试验研究.pdfVIP

symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study在创伤后应激障碍症状的持久性和记忆表现基因x环境试验研究.pdf

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symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study在创伤后应激障碍症状的持久性和记忆表现基因x环境试验研究

Behav. Sci. 2012, 2, 103-114; doi:10.3390/bs2020103 OPEN ACCESS Behavioral Sciences ISSN 2076-328X /journal/behavsci/ Aticle Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study Annie-Claude David 1,2, Geeta A. Thakur 2,3, Vivian Akerib 2, Jorge Armony 2,3, Isabelle Rouleau 1 and Alain Brunet 2,3,* 1 Department of Psychology, Université du Québec à Montréal, Montreal H2X 1L7, Canada; E-Mails: annieclaude.david@ (A.-C.D.); rouleau.isabelle@uqam.ca (I.R.) 2 Douglas Mental Health University Institute, Montreal H4H 1R2, Canada; E-Mails: geeta.thakur@douglas.mcgill.ca (G.A.T.); vakerib@videotron.ca (V.A.); jorge.armony@mcgill.ca (J.A.) 3 Department of Psychiatry, McGill University, Montreal H3A 0G4, Canada * Author to whom correspondence should be addressed; E-Mail: alain.brunet@mcgill.ca; Tel.: +1-514-761-6131 (ex 2375); Fax: +1-514-762-3049. Received: 25 April 2012; in revised form: 24 May 2012 / Accepted: 24 May 2012 / Published: 1 June 2012 Abstract: The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limit

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