study on the stability of deoxyarbutin in an anhydrous emulsion systemy研究无水乳液systemy deoxyarbutin的稳定性.pdfVIP
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study on the stability of deoxyarbutin in an anhydrous emulsion systemy研究无水乳液systemy deoxyarbutin的稳定性
Int. J. Mol. Sci. 2011, 12, 5946-5954; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Study on the Stability of DeoxyArbutin in an Anhydrous
Emulsion System
Chih-Chien Lin 1,*, Chao-Hsun Yang 1, Nai-Fang Chang 1, Pey-Shiuan Wu 1, Yi-Shyan Chen 1,
2 1
Shu-Mei Lee and Chiu-Wen Chen
1 Department of Cosmetic Science, Providence University, 200 Chung-Chi Road, Shalu,
Taichung 43301, Taiwan; E-Mails: chyang@.tw (C.-H.Y.); nfchang@.tw (N.-F.C.);
jwu2@.tw (P.-S.W.); yishyan@.tw (Y .-S.C.); rita770115@ (C.-W.C.)
2 Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management
College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan; E-Mail: s107@.tw
* Author to whom correspondence should be addressed; E-Mail: chchlin@.tw;
Tel.: +886-4ext. 15409; Fax: +886-4
Received: 3 August 2011; in revised form: 1 September 2011 / Accepted: 7 September 2011 /
Published: 15 September 2011
Abstract: The skin-whitening agent, deoxyArbutin, is a potent tyrosinase inhibitor that is
safer than hydroquinone and arbutin. However, it is thermolabile in aqueous solutions,
where it decomposes to hydroquinone. Pharmaceutical and cosmetic emulsions are
normally oil-in-water (o/w) or water-in-oil (w/o) systems; however, emulsions can be
formulated with no
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