synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics合成及抗菌活性的杂环查耳酮类似物,结合抗生素.pdfVIP

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synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics合成及抗菌活性的杂环查耳酮类似物,结合抗生素.pdf

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synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics合成及抗菌活性的杂环查耳酮类似物,结合抗生素

Molecules 2012, 17, 6684-6696; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antibacterial Activity of Some Heterocyclic Chalcone Analogues Alone and in Combination with Antibiotics Thanh-Dao Tran 1,*, Thi-Thao-Nhu Nguyen 1, Tuong-Ha Do 2, Thi-Ngoc-Phuong Huynh 1, Cat-Dong Tran 3 and Khac-Minh Thai 1,* 1 Department of Medicinal Chemistry, School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Dist. 1, Ho Chi Minh City 70000, Vietnam; E-Mails: thaonhu1986@ (T.-T.-N.N.); ngocphuonght@ (T.-N.-P.H.) 2 Department of Synthetic/Organic Chemistry, Ton Duc Thang University, Nguyen Huu Tho St., Tan Phong Ward, Dist. 7, Ho Chi Minh City 70000, Vietnam; E-Mail: dtuongha@ 3 Department of Microbiology, School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Dist. 1, Ho Chi Minh City 70000, Vietnam; E-Mail: trancdong@ * Authors to whom correspondence should be addressed; E-Mails: thanhdaot@ or tranthanhdao@.vn (T.-D.T.); thaikhacminh@ or thaikhacminh@.vn (K.-M.T.); Tel.: +84-903-716-482 (T.-D.T.); +84-909-680-385 (K.-M.T.); Fax: +84-8-3822-5435. Received: 7 May 2012; in revised form: 25 May 2012 / Accepted: 30 May 2012 / Published: 1 June 2012 Abstract: A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The