submesothelial deposition of carbon nanoparticles after toner exposition case reportsubmesothelial墨粉博览会病例报告后沉积的碳纳米颗粒.pdfVIP

Theegarten et al. Diagnostic Pathology 2010, 5:77 /content/5/1/77 CASE REPORT Open Access Submesothelial deposition of carbon nanoparticles after toner exposition: Case report 1* 2 3 1,4 Dirk Theegarten , Smail Boukercha , Stathis Philippou , Olaf Anhenn Abstract Inhalation of carbon nanoparticles (CNP) from toner dust has been shown to have impact on the respiratory health of persons exposed. Office printers are known emitters of CNP. We report about a female open office worker who developed weight loss and diarrhoea. Laparoscopy done for suspected endometriosis surprisingly revealed black spots within the peritoneum. Submesothelial aggregates of CNP with a diameter of 31-67 nm were found by scan- ning and transmission electron microscopy in these tissue specimens. Colon biopsies showed inflammatory bowel disease with typically signs of Crohn disease, but no dust deposits. Transport of CNP via lymphatic and blood ves- sels after inhalation in the lungs has to be assumed. In this case respiratory symptoms were not reported, therefore no lung function tests were done. We have shown that workers with toner dust exposure from laser printers can develop submesothelial deposition of CNP in the peritoneum. Impact of toner dust exposure on the respiratory health of office workers, as suspected in other studies, has to be evaluated further. Background since three months. Biopsies taken during two colosco- Several studies have reported that laser printers are sig- pies revealed no changes according to the first interpre- nificant sources of ultrafine particles [1-6]. Workers tation at another institution. Therefore her gynecologist with long time expos