substituted amides of pyrazine-2-carboxylic acids synthesis and biological activity取代的酰胺pyrazine-2-carboxylic酸合成和生物活性.pdfVIP

substituted amides of pyrazine-2-carboxylic acids synthesis and biological activity取代的酰胺pyrazine-2-carboxylic酸合成和生物活性.pdf

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  4. 4、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  5. 5、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  6. 6、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  7. 7、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
substituted amides of pyrazine-2-carboxylic acids synthesis and biological activity取代的酰胺pyrazine-2-carboxylic酸合成和生物活性

Molecules 2002, 7, 363-373 molecules ISSN 1420-3049 Substituted Amides of Pyrazine-2-carboxylic acids: Synthesis and Biological Activity. 1 1 2 3 Martin Dolezal *, Miroslav Miletin , Jiri Kunes , Katarina Kralova 1 Department of Pharmaceutical Chemistry and Drug Control and 2 Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, 500 05 Hradec Kr·lovÈ, Czech Republic, Tel.: +420 49 5067272; Fax +420 49 5512423. 3 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, 842 15 Bratislava, Slovak Republic. * Author to whom correspondence should be addressed; e-mail: dolezalm@faf.cuni.cz Received: 24 October 2001; in revised form: 12 March 2002 / Accepted: 22 March 2002 / Published: 31 March 2002 Abstract: Condensation of 6-chloro-, 5-tert-butyl- or 6-chloro-5-tert-butylpyrazine-2- carboxylic acid chloride with ring substituted anilines yielded a series of amides, which were tested for their in vitro antimycobacterial, antifungal and photosynthesis-inhibiting activities. The highest antituberculotic activity (72% inhibition) against Mycobacterium tuberculosis and the highest lipophilicity (log P = 6.85) were shown by the 3,5-bis- trifluoromethylphenyl amide of 5-tert-butyl-6-chloropyrazine-2-carboxylic acid (2o). The 3-methylphenyl amides of 6-chloro- and 5-tert-butyl-6-chloro-pyrazine-2-carboxylic acid (2d and 2f) exhibited only a poor in

您可能关注的文档

文档评论(0)

118zhuanqian + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档