原创力文档stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of appps1 transgenic mice干细胞因子和粒细胞集落刺激因子减少β-amyloid存款appps1转基因小鼠的大脑中.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of appps1 transgenic mice干细胞因子和粒细胞集落刺激因子减少β-amyloid存款appps1转基因小鼠的大脑中
Li et al. Alzheimer ’s Research Therapy 2011, 3:8
/content/3/2/8
RESEARCH Open Access
Stem cell factor and granulocyte colony-
stimulating factor reduce b-amyloid deposits in
the brains of APP/PS1 transgenic mice
1 1 1 2 1,3 1,4*
Bin Li , Maria E Gonzalez-Toledo , Chun-Shu Piao , Allen Gu , Roger E Kelley and Li-Ru Zhao
Abstract
Introduction: Alzheimer’s disease (AD) is widely recognized as a serious public health problem and heavy financial
burden. Currently, there is no treatment that can delay or stop the progressive brain damage in AD. Recently, we
demonstrated that stem cell factor (SCF) in combination with granulocyte colony-stimulating factor (G-CSF) (SCF
+G-CSF) has therapeutic effects on chronic stroke. The purpose of the present study is to determine whether SCF
+G-CSF can reduce the burden of b-amyloid deposits in a mouse model of AD.
Methods: APP/PS1 transgenic mice were used as the model of AD. To track bone marrow-derived cells in the
brain, the bone marrow of the APP/PS1 mice was replaced with the bone marrow from mice expressing green
fluorescent protein (GFP). Six weeks after bone marrow transplantation, mice were randomly divided into a saline
control group and a SCF+G-CSF-treated group. SCF in combination with G-CSF was administered subcutaneously
for 12 days. Circulating bone marrow stem cells (CD117+ cells) were quantified 1 day after the final injection. Nine
months after treatment, at the age of 18 months, mice were sacrificed. Brain sections were processed for
immunohistochemistry to identify b-amyloid deposits and GFP expressing bone marrow-derived microglia in the
brain.
Results: Systemic administration of SCF+G-CSF to APP/PS1 transgenic mice leads to long-t
您可能关注的文档
- solvent and ligand effects on the tandem addition-lithiation-electrophilic substitution of phenyllithium on α,β-unsaturated carbonyl compounds溶剂和配位效应的串联addition-lithiation-electrophilic替换phenyllithiumα,β-unsaturated羰基化合物.pdf
- solvent effects in electrocoagulation of selected plant pigments and tannin溶剂效应的电凝法选择的植物色素和单宁.pdf
- solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料.pdf
- solvent effects on nuclear magnetic resonance 2j(c,hf) and 1j(c,hf) spin–spin coupling constants in acetaldehyde溶剂对核磁共振的影响2 j(c,高频)和1(c hf)自旋自旋耦合常数乙醛.pdf
- solvent effects on the indirect spin–spin coupling constants of benzene the dft-pcm approach溶剂的影响间接自旋自旋耦合常数dft-pcm苯的方法.pdf
- solution-phase synthesis of a combinatorial library of 3-[4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides组合库的液相合成3 -[4 -(coumarin-3-yl)1,3-thiazol-2-ylcarbamoyl]丙酸酰胺.pdf
- soluble receptor activator of nuclear factor κb ligandosteoprotegerin ratio is increased in systemic lupus erythematosus patients可溶性受体激活核因子κb ligandosteoprotegerin系统性红斑狼疮患者的比例增加.pdf
- solvent free, microwave assisted conversion of aldehydes into nitriles and oximes in the presence of nh2oh·hcl and tio2无溶剂、微波辅助醛转化为腈、肟的回复·盐酸和二氧化钛.pdf
- solvent vapour detection with cholesteric liquid crystals—optical and mass-sensitive evaluation of the sensor mechanism溶剂蒸汽检测和胆甾型液体crystals-optical mass-sensitive评估传感器机制.pdf
- solvent-free synthesis of modified pectin compounds promoted by microwave irradiation无溶剂合成改性果胶化合物由微波辐射.pdf
- stefan problem through extended finite elements review and further investigations通过扩展有限元素stefan问题检查和进一步的调查.pdf
- steering a tractor by means of an emg-based human-machine interface驾驶一辆拖拉机通过emg-based人机界面.pdf
- stem cell proliferation during in vitro development of the model cestode mesocestoides corti from larva to adult worm干细胞在体外增殖发展模型的绦虫mesocestoides螺旋器从幼虫到成人的蠕虫.pdf
- stem cell tracking by nanotechnologies干细胞通过纳米技术跟踪.pdf
- stem cell transplantation for primary immunodeficiency disease experience of a singapore hospital原发性免疫缺陷疾病的干细胞移植新加坡医院的经验.pdf
- stem cells and neuroprotection understanding the players干细胞和神经保护理解球员们.pdf
- stem cell transplantation for type 1 diabetes mellitus干细胞移植为1型糖尿病.pdf
- stem cell-based neuroprotective and neurorestorative strategies干细胞神经保护和neurorestorative策略.pdf
- stem cells for the treatment of neurodegenerative diseases干细胞治疗神经退行性疾病.pdf
- stem cell therapy a new treatment for burns干细胞疗法治疗烧伤的新方法.pdf
文档评论（0）