原创力文档synthesis and anticancer activity of di(3-thienyl)methanol and di(3-thienyl)methane合成和抗癌活性的di(3-thienyl)甲醇和di(3-thienyl)甲烷.pdfVIP
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synthesis and anticancer activity of di(3-thienyl)methanol and di(3-thienyl)methane合成和抗癌活性的di(3-thienyl)甲醇和di(3-thienyl)甲烷
Molecules 2012, 17, 11456-11468; doi:10.3390/molecules171011456
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Anticancer Activity of Di(3-thienyl)methanol and
Di(3-thienyl)methane
1 2 2 2
Nagendra Kumar Kaushik , Hong Seon Kim , Young June Chae , Young Nam Lee ,
Gi-Chung Kwon 1, Eun Ha Choi 1 and In Tae Kim 2,*
1 Plasma Bioscience Research Center, Kwangwoon University, Seoul 139-701, Korea
2 Department of Chemistry, Kwangwoon University, Seoul 139-701, Korea
* Author to whom correspondence should be addressed; E-Mail: itkim@kw.ac.kr;
Tel.: +82-10-3795-1479; Fax: +82-2-909-1978.
Received: 2 August 2012; in revised form: 24 September 2012 / Accepted: 25 September 2012 /
Published: 27 September 2012
Abstract: Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized
and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT
and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation),
were studied as cellular response parameters. Treatment with the compounds enhanced
growth inhibition and cell death in a concentration dependent manner in both T98G and
HEK (normal) cell lines. At higher concentrations (20 µg/mL) the cytotoxic effects of the
compounds were highly significant. The effect on clonogenic capacity and micronuclei
formation observed after treatment of c
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