synthesis and antifungal activity of n-(substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxamide derivatives合成和抗真菌活性的n -(取代pyridinyl)1号(苯)3 -(trifluoromethyl)1 h-pyrazole-4-carboxamide衍生品.pdfVIP

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synthesis and antifungal activity of n-(substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxamide derivatives合成和抗真菌活性的n -(取代pyridinyl)1号(苯)3 -(trifluoromethyl)1 h-pyrazole-4-carboxamide衍生品.pdf

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synthesis and antifungal activity of n-(substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxamide derivatives合成和抗真菌活性的n -(取代pyridinyl)1号(苯)3 -(trifluoromethyl)1 h-pyrazole-4-carboxamide衍生品

Molecules 2012, 17, 14205-14218; doi:10.3390/molecules171214205 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antifungal Activity of N-(Substituted pyridinyl)- 1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4- carboxamide Derivatives Zhibing Wu, Deyu Hu, Jiqing Kuang, Hua Cai, Shixi Wu and Wei Xue * State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China; E-Mails: wzb1171@163.com (Z.W.); fcc.dyhu@ (D.H.); kuangjiqing@ (J.K.); woshicaihua@126.com (H.C.); gzushixiwu@163.com (S.W.) * Author to whom correspondence should be addressed; E-Mail: shouldww@126.com; Tel./Fax: +86-851-8292-090. Received: 18 October 2012; in revised form: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012 Abstract: A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H- pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data (1H-NMR, 13C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and