synthesis and antimicrobial activity of some derivatives on the basis (7-hydroxy-2-oxo-2h-chromen-4-yl)-acetic acid hydrazide合成及抗菌活性的基础上衍生品(7-hydroxy-2-oxo-2h-chromen-4-yl)乙酸酸酰肼.pdfVIP

下载本文档

4
0
约4.96万字
约 14页
2017-09-12 发布于上海
举报
版权申诉

synthesis and antimicrobial activity of some derivatives on the basis (7-hydroxy-2-oxo-2h-chromen-4-yl)-acetic acid hydrazide合成及抗菌活性的基础上衍生品(7-hydroxy-2-oxo-2h-chromen-4-yl)乙酸酸酰肼.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis and antimicrobial activity of some derivatives on the basis (7-hydroxy-2-oxo-2h-chromen-4-yl)-acetic acid hydrazide合成及抗菌活性的基础上衍生品(7-hydroxy-2-oxo-2h-chromen-4-yl)乙酸酸酰肼

Molecules 2006, 11, 134-147 molecules ISSN 1420-3049 Full Research Paper Synthesis and Antimicrobial Activity of Some Derivatives of (7- Hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide Milan Cacic 1,*, Mladen Trkovnik 2, Frane Cacic 1,† and Elizabeta Has-Schon 3 1 Department of Chemistry, Faculty of Food Technology, J.J. Strossmayer University, Franje Kuhaca 18, 31 000 Osijek, Croatia; † E-mail: fcacic@ptfos.hr 2 F. Malnara 8, odvojak 7, 10 000 Zagreb, Croatia 3 Department of Biology, J.J. Strossmayer University, Gajev Trg 6, 31000 Osijek, Croatia; E-mail: elschon@ * Author to whom correspondence should be addressed; E-mail: mcacic@ptfos.hr Received: 31 January 2006 / Accepted: 3 March 2006 / Published: 7 March 2006 Abstract: (7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate. Compound 2, is the key intermediate for the synthesis of several series of new compounds such as Schiff’s bases 3a-l, formic acid N-[2-(7-hydroxy-2-oxo-2H- chromen-4-yl)acetyl] hydrazide (4), acetic acid N-[2-(7-hydroxy-2-oxo-2H-chromen-4- yl)-acetyl] hydrazide (5), (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid N-[2-(4- hydroxy-2-oxo-2H-chromen-3-yl)-2-oxoethyl] hydrazide (6), 4-phenyl-1-(7-hydroxy-2- oxo-2H-chromen- 4-acetyl) thiosemicarbazide (7), ethyl 3-{2-[2-(7-hydroxy-2-oxo-2H- chromen-4-yl)-acetyl]hydrazono}butanoate (8), (7-hydroxy-2-oxo-2H-chromen-4-yl)- acetic acid N-[(4-trifluoromet