原创力文档synthesis and antimicrobial activity of some new quinoxaline derivatives一些新的喹喔啉衍生物的合成及抗菌活性.pdfVIP
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synthesis and antimicrobial activity of some new quinoxaline derivatives一些新的喹喔啉衍生物的合成及抗菌活性
Pharmaceuticals 2010, 3, 2416-2425; doi:10.3390/ph3082416
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Article
Synthesis and Antimicrobial Activity of Some New
Quinoxaline Derivatives
Dharmchand Prasad Singh 1,*, Sanjay Kumar Deivedi 1, Syed Riaz Hashim 1
2
and Ram Gopal Singhal
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and
Management, Moradabad - 244001, India; E-Mails: sanjaydeivedi@yahoo.co.in (S.K.D.);
sriaz_hashim@ (S.R.H.)
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, India;
E-Mail: drrgsinghal@ (R.G.S.)
* Author to whom correspondence should be addressed; E-Mail: dcp_singh@;
Tel.: +91-983-708-5047; Fax: +91-591-236-0818.
Received: 25 May 2010; in revised form: 13 July 2010 / Accepted: 16 July 2010 /
Published: 30 July 2010
Abstract: 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various
molecular transformations were performed to obtain new compounds expected to possess
optimized antimicrobial activity. As very little work regarding attachment of ether linkages
replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize
various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached
to a benzene ring possessing an aldehyde or a free amino group which can be further
reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff
bases conta
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