原创力文档synthesis and antifungal evaluation of 1-aryl-2-dimethyl-aminomethyl-2-propen-1-one hydrochlorides合成和抗真菌的评价1-aryl-2-dimethyl-aminomethyl-2-propen-1-one盐酸盐.pdfVIP
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synthesis and antifungal evaluation of 1-aryl-2-dimethyl-aminomethyl-2-propen-1-one hydrochlorides合成和抗真菌的评价1-aryl-2-dimethyl-aminomethyl-2-propen-1-one盐酸盐
Molecules 2011, 16, 4660-4671; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Antifungal Evaluation of 1-Aryl-2-dimethyl-
aminomethyl-2-propen-1-one Hydrochlorides
Ebru Mete 1,*, Halise Inci Gul 2, Sinan Bilginer 2, Oztekin Algul 3, Mehmet Emin Topaloglu 2,
4 1
Medine Gulluce and Cavit Kazaz
1 Department of Chemistry, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University,
25240, Erzurum, Turkey
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University,
33169, Mersin, Turkey
4 Department of Biology, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey
* Author to whom correspondence should be addressed; E-Mail: ebru25@.tr;
Tel.: +90-442-2314407; Fax: +90-442-2360962.
Received: 15 March 2011; in revised form: 27 May 2011 / Accepted: 31 May 2011 /
Published: 3 June 2011
Abstract: The development of resistance to current antifungal therapeutics drives the
search for new effective agents. The fact that several acetophenone-derived Mannich bases
had shown remarkable antifungal activities in our previous studies led us to design and
synthesize some acetophenone-derived Mannich bases, 1-8 and 2-acetylthiophene-derived
Mannich base 9, 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochloride, to evaluate
their antifungal activities. The designed
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