synthesis and crystal structure of 3-(4-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1h)-one合成和晶体结构的3 -(4-methoxyphenyl)2-thioxo-2 3-dihydroquinazolin-4u2014u2014(1 h).pdfVIP

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synthesis and crystal structure of 3-(4-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1h)-one合成和晶体结构的3 -(4-methoxyphenyl)2-thioxo-2 3-dihydroquinazolin-4u2014u2014(1 h).pdf

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synthesis and crystal structure of 3-(4-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1h)-one合成和晶体结构的3 -(4-methoxyphenyl)2-thioxo-2 3-dihydroquinazolin-4u2014u2014(1 h)

Crystals 2011, 1, 171-177; doi:10.3390/cryst1030171 OPEN ACCESS crystals ISSN 2073-4352 /journal/crystals Communication Synthesis and Crystal Structure of 3-(4-Methoxyphenyl)-2- thioxo-2,3-dihydroquinazolin-4(1H)-one Aamer Saeed 1, *, Shams ul Mahmood 1 and H. Ishida 2 1 Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan 2 Department of Chemistry, Faculty of Science, Okayama University, Okayama, 700-8530, Japan * Author to whom correspondence should be addressed; E-Mail: aamersaeed@; Tel.: +92-51-9064-2128; Fax: +92-51-9064-2241. Received: 13 July 2011; in revised form: 19 September 2011 / Accepted: 24 August 2011 / Published: 29 August 2011 Abstract: Synthesis of the title compound from 4-methoxyaniline was accomplished in three steps. The structure was supported by spectroscopic data and unambiguously confirmed by single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions a = 9.9349(8), b = 6.3377(5), c = 10.5783(10) Å, 3 β = 97.752(3)°, V = 659.97(10) Å , Z = 2. Keywords: quinazolinone; 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones; synthesis 1. Introduction Quinazolinone is the building unit of approximately 150 naturally occurring alkaloids isolated from microorganisms, plants and animals [1]. It is a very important heterocycle exhibiting excellent pharmacological activiti