synthesis and cytotoxic activity of some 3-benzyl-5-arylidenefuran-2(5h)-ones合成和细胞毒性的活动有些3-benzyl-5-arylidenefuran-2(5 h)的.pdfVIP

下载本文档

2
0
约5.93万字
约 16页
2017-09-12 发布于上海
举报
版权申诉

synthesis and cytotoxic activity of some 3-benzyl-5-arylidenefuran-2(5h)-ones合成和细胞毒性的活动有些3-benzyl-5-arylidenefuran-2(5 h)的.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis and cytotoxic activity of some 3-benzyl-5-arylidenefuran-2(5h)-ones合成和细胞毒性的活动有些3-benzyl-5-arylidenefuran-2(5 h)的

Molecules 2007, 12, 1101-1116 molecules ISSN 1420-3049 © 2007 by MDPI /molecules Full Paper Synthesis and Cytotoxic Activity of Some 3-Benzyl-5-Arylidenefuran-2(5H)-ones Róbson Ricardo Teixeira 1,2, Luiz Cláudio Almeida Barbosa 1,*, Célia Regina Alvares Maltha 1, Marcelo Eça Rocha 1, Daniel Pereira Bezerra 3, Letícia Veras Costa-Lotufo 3, Cláudia Pessoa 3 3 and Manoel Odorico Moraes 1 Department of Chemistry, Federal University of Viçosa, Av. P.H. Rolfs, S/N, CEP 36570-000, Viçosa, MG, Brazil 2 Department of Chemistry, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte, MG, Brazil 3 Department of Physiology and Pharmacology, Federal University of Ceará, Rua Coronel Nunes de Melo, 1127, CEP 60431-970, Fortaleza, CE, Brazil * Author to whom correspondence should be addressed; E-mail: lcab@ufv.br; Tel.: (+55) 31 3899 3068; Fax: (+55) 31 3899 3065 Received: 26 April 2007; in revised form: 21 May 2007 / Accepted: 21 May 2007 / Published: 24 May 2007 Abstract: 3-Benzyl-furan-2(5H)-one (2a) and 3-(4-bromobenzyl)-furan-2(5H)-one (2b) were treated with TBDMSOTf and converted into the corresponding tert-butyldimethyl- silylfuran ethers. These furans were further condensed with several aromatic aldehydes affording compounds 5-14 with general 3-benzyl-5-arylidene-furan-2(5H)-one structures in 31% to 98% yields. Such compounds are analogues of the naturally occurring nostoclide lactones, reported to present moderate