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synthesis and effect on human hepg2 cells of 1,2-bis- (2-methylallyl)disulfane对人类hepg2细胞合成和影响,以叔u2014u2014disulfane(2-methylallyl)
Molecules 2010, 15, 3634-3642; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Effect on Human HepG2 Cells of 1,2-bis-
(2-Methylallyl)disulfane
Chunxiao Ji 1,*, Fenglian Ren 1, Jun Dai 1 and Ming Xu 2
1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan
410083, China; E-Mail: renfl2009@ (F.R.)
2 Research Institute for Molecular Pharmacology and Therapeutics, Central South University,
Changsha, Hunan 410083, China
Author to whom correspondence should be addressed; E-Mail: cx312@163.com.
Received: 16 April 2010; in revised form: 11 May 2010 / Accepted: 12 May 2010 /
Published: 18 May 2010
Abstract: 1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and
3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS,
1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein
expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit
the proliferation, and induce the apoptosis of human HepG2 cells.
Key words: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis
1. Introduction
Garlic is a kind of liliaceae allium, and allicin is the general name for the main bioactive
components of garlic, which is a mixture of a variety of allyl sulfides, including diallytrisulfide
compounds (DATS), diallyl disulfide compounds (DADS) and many kinds of thioethers. All
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