原创力文档synthesis and evaluation of new β-carboline-3-(4-benzylidene)-4h-oxazol-5-one derivatives as antitumor agents(合成和评估新的β-carboline-3)- 4-benzylidene 4 h-oxazol-5-one衍生品作为抗肿瘤剂.pdfVIP
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synthesis and evaluation of new β-carboline-3-(4-benzylidene)-4h-oxazol-5-one derivatives as antitumor agents(合成和评估新的β-carboline-3)- 4-benzylidene 4 h-oxazol-5-one衍生品作为抗肿瘤剂
Molecules 2012, 17, 6100-6113; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-
4H-oxazol-5-one Derivatives as Antitumor Agents
Franciele Cristina Savariz 1, Mary Ann Foglio 2, João Ernesto de Carvalho 2, Ana Lúcia T. G. Ruiz 2,
2 3 1
Marta C. T. Duarte , Mauricio Ferreira da Rosa , Emerson Meyer and
Maria Helena Sarragiotto 1,*
1 Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Maringá,
Av. Colombo, 5790, Maringá, 87020-900 PR, Brazil
2 Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA),
Universidade Estadual de Campinas, 6171, Campinas, 13083-970 SP, Brazil
3 Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná,
Rua da Faculdade, 645, Toledo, 85903-000 PR, Brazil
* Author to whom correspondence should be addressed; E-Mail: mhsarragiotto@uem.br;
Tel.: +55-44-3261-3657; Fax: +55-44-3011-4125.
Received: 5 April 2012; in revised form: 5 May 2012 / Accepted: 7 May 2012 /
Published: 21 May 2012
Abstract: In the present work, we report the synthesis and in vitro anticancer and
antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives
bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4-
methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-on
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