原创力文档synthesis and evaluation of non-peptidic cysteine protease inhibitors of p. falciparum derived from etacrynic acid合成和评价non-peptidic半胱氨酸蛋白酶抑制剂的恶性疟原虫源自etacrynic酸.pdfVIP
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synthesis and evaluation of non-peptidic cysteine protease inhibitors of p. falciparum derived from etacrynic acid合成和评价non-peptidic半胱氨酸蛋白酶抑制剂的恶性疟原虫源自etacrynic酸
Molecules 2009, 14, 19-35; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis and Evaluation of Non-peptidic Cysteine Protease
Inhibitors of P. falciparum Derived from Etacrynic Acid
1 2 2 2
Marie-Adrienne Dude , Ulrich Kaeppler , Monika Herb , Markus Schiller , Franziska
3 2 3 1 4 4
Schulz , Birgit Vedder , Saskia Heppner , Gabriele Pradel , Jiri Gut , Philip J. Rosenthal ,
Tanja Schirmeister 2, Matthias Leippe 3 and Christoph Gelhaus 3,*
1 Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070
Würzburg, Germany; E-mail: adrienne.dude@uni-wuerzburg.de (M-A. D.),
gabriele.pradel@mail.uni-wuerzburg.de (G. P.)
2 Institute of Pharmacy and Food Chemistry, Am Hubland, D-97074 Würzburg, Germany
E-mail: schirmei@pharmazie.uni-wuerzburg.de (T. S.)
3 Zoological Institute, University of Kiel, Olshausenstr. 40, D-24098 Kiel, Germany
E-mail: mleippe@zoologie.uni-kiel.de (M. L.)
4 Department of Medicine, San Francisco General Hospital, University of California, San Francisco,
CA 94143-0811, USA; E-mail: philip.rosenthal@ (P-J. R.)
* Author to whom correspondence should be addressed; E-mail: cgelhaus@zoologie.uni-kiel.de.
Received: 20 November 2008; in revised form: 12 December 2008 / Accepted: 19 December 2008 /
Published: 23 December 2008
Abstract: A series
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