targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing clostridium difficile disease in mice恢复肠道菌群与一个简单的目标,定义梭状芽胞杆菌细菌疗法解决复发疾病在老鼠身上.pdfVIP

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2017-09-12 发布于上海
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targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing clostridium difficile disease in mice恢复肠道菌群与一个简单的目标,定义梭状芽胞杆菌细菌疗法解决复发疾病在老鼠身上.pdf

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targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing clostridium difficile disease in mice恢复肠道菌群与一个简单的目标,定义梭状芽胞杆菌细菌疗法解决复发疾病在老鼠身上

Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice 1 1. 1. 1 1 1 Trevor D. Lawley *, Simon Clare , Alan W. Walker , Mark D. Stares , Thomas R. Connor , Claire Raisen , 1 1 1 1 1 David Goulding , Roland Rad , Fernanda Schreiber , Cordelia Brandt , Laura J. Deakin , 1 2 2 3 1 1 Derek J. Pickard , Sylvia H. Duncan , Harry J. Flint , Taane G. Clark , Julian Parkhill , Gordon Dougan 1 Wellcome Trust Sanger Institute, Hinxton, United Kingdom, 2 Rowett Institute of Nutrition and Health, Aberdeen, United Kingdom, 3 London School of Hygiene and Tropical Medicine, London, United Kingdom Abstract Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C. difficile (genotype 027/BI) develop highly contagious, chronic intestinal disease and persistent dysbiosis characterized by a distinct, simplified microbiota containing opportunistic pathogens and altered metabolite production. Chronic C. difficile 027/BI infection was refractory to vancomycin treatment leading to relapsing disease. In contrast, treatment of C. difficile 027/BI infected mice with feces from healthy