原创力文档targeting protective autophagy exacerbates uv-triggered apoptotic cell death针对保护性自噬加剧uv引起的凋亡细胞死亡.pdfVIP
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targeting protective autophagy exacerbates uv-triggered apoptotic cell death针对保护性自噬加剧uv引起的凋亡细胞死亡
Int. J. Mol. Sci. 2012, 13, 1209-1224; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Targeting Protective Autophagy Exacerbates UV-Triggered
Apoptotic Cell Death
Li-Hsin Chen 1, Pei-Ming Chu 2, Yi-Jang Lee 3, Pang-Hsien Tu 4, Chin-Wen Chi 1,5,
Hsin-Chen Lee 1,* and Shih-Hwa Chiou 1,5,*
1 Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 11221,
Taiwan; E-Mails: jenhsinchen@ (L.-H.C.); cwchi@.tw (C.-W.C.)
2 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan;
E-Mail: chupeiming@.tw
3 Department of Biomedical Image and Radiological Sciences, School of Biomedical Science and
Engineering, National Yang-Ming University, Taipei 11221, Taiwan; E-Mail: yjlee2@.tw
4 Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan;
E-Mail: btu@.tw
5 Department of Medical Research and Education, Taipei Veterans General Hospital,
Taipei 11217, Taiwan
* Authors to whom correspondence should be addressed; E-Mails: hclee2@.tw (H.-C.L.);
shchiou@.tw (S.-H.C.); Tel.: +886-2(H.-C.L.); +886-2(S.-H.C.);
Fax: +886-2
Received: 12 December 2011; in revised form: 10 January 2012 / Accepted: 12 January 2012 /
Published: 20 January 2012
Abstract: Autophagy is activated by various stresses, including DNA damage, and
previous studies of DNA damage-induced autophagy have focused
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