targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive b cells as a therapy for lupus针对toll样受体信号在血浆树突细胞和autoreactive b细胞治疗红斑狼疮.pdfVIP

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targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive b cells as a therapy for lupus针对toll样受体信号在血浆树突细胞和autoreactive b细胞治疗红斑狼疮.pdf

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targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive b cells as a therapy for lupus针对toll样受体信号在血浆树突细胞和autoreactive b细胞治疗红斑狼疮

Available online /content/8/1/203 Review Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus Petar S Lenert Assistant Professor, Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA Corresponding author: Petar S Lenert, petar-lenert@ Published: 10 January 2006 Arthritis Research Therapy 2006, 8:203 (doi:10.1186/ar1888) This article is online at /content/8/1/203 © 2006 BioMed Central Ltd Abstract limited heterogeneity [4] but they have potent capacity to This review focuses on the role of Toll-like receptors (TLRs) in sense micro-organisms and alert body defense system about lupus and on possibilities to treat lupus using TLR modulating the presence of infectious danger. This is achieved through inhibitory oligodeoxynucleotides (INH-ODNs). TLRs bridge innate recognition of conserved microbial patterns such as and adaptive immune responses and may play an important role in unmethylated CpG motifs in bacterial DNA [5], single- the pathogenesis of systemic lupus erythematosus. Of particular stranded or double-stranded (ds) viral RNA, lipopoly- interest are TLR3, -7, -8, and -9, which are localized intracellularly. saccharide, peptidoglycan, and bacterial flagellin (for review, These TLRs recognize single-stranded or double-stranded RNA or hypomethylated CpG-DNA. Exposure to higher order CpG-DNA see [6]). However, the role of TLRs extends beyond microbial ligands or t