tgf-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibilitytgf-b2感应调节theileria-transformed白细胞和疾病易感性的侵蚀.pdfVIP

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tgf-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibilitytgf-b2感应调节theileria-transformed白细胞和疾病易感性的侵蚀.pdf

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tgf-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibilitytgf-b2感应调节theileria-transformed白细胞和疾病易感性的侵蚀

TGF-b2 Induction Regulates Invasiveness of Theileria- Transformed Leukocytes and Disease Susceptibility Marie Chaussepied1,2., Natacha Janski3,4., Martin Baumgartner5., Regina Lizundia1,2,6, Kirsty Jensen7, 8 8 3,4 7 6 William Weir , Brian R. Shiels , Jonathan B. Weitzman , Elizabeth J. Glass , Dirk Werling , Gordon Langsley1,2* ´ ´ 1 Institut Cochin, Universite Paris-Descartes, CNRS (UMR 8104), Paris, France, 2 Inserm U1016, Paris, France, 3 Universite Paris-Diderot Paris 7, Paris, France, 4 CNRS ´ ´ UMR7216 Epigenetique et Destin Cellulaire, Paris, France, 5 University of Berne, Department of Clinical Research and Veterinary Public Health, Division Molecular Pathobiology, Bern, Switzerland, 6 Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom, 7 Division of Genetics and Genomics, The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin, Midlothian, United Kingdom, 8 Division of Veterinary Infection and Immunity, University of Glasgow, Faculty of Veterinary Medicine, Institute of Comparative Medicine, Bearsden Road, Glasgow, United Kingdom Abstract Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced pathology, suggesting that host genetic factors may cause disease susceptibility. Attenuated live vaccines are widely used to co