th1 and th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritisth1、th2细胞因子调节proteoglycan-specific自身抗体同形像和关节炎.pdfVIP

Available online /content/4/1/054 Research article Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis † ‡ ‡ § ‡† Charles Kaplan , Juan C Valdez , Raman Chandrasekaran , Hermann Eibel , Katalin Mikecz , Tibor T Glant*‡ and Alison Finnegan*† *Department of Medicine, Section of Rheumatology, Rush Presbyterian–St Luke’s Medical Center, Chicago, IL, USA †Department of Immunology/Microbiology, Rush Presbyterian–St Luke’s Medical Center, Chicago, IL, USA ‡Departments of Orthopedic Surgery and Biochemistry, Rush Presbyterian–St Luke’s Medical Center, Chicago, IL, USA §Klinische Forschergruppe für Rheumatologie, Freiburg, Germany Correspondence: Alison Finnegan, PhD, Department of Medicine, Section of Rheumatology, Rush–Presbyterian St Luke’s Medical Center, 1735 West Harrison Avenue, Chicago, IL 60612, USA. Tel: +1 312 942 7847; fax: +1 312 942 8828; e-mail: afinnega@ Received: 19 June 2001 Arthritis Res 2002, 4:54-58 Revisions requested: 15 August 2001 This article may contain supplementary data which can only be found Revisions received: 20 August 2001 online at /content/4/1/054 Accepted: 5 September 2001 © 2002 Kaplan et al., licensee BioMed Central Ltd Published: 2 October 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype