the antiviral activities and mechanisms of marine polysaccharides an overview海洋多糖的抗病毒活动和机制概述.pdfVIP

Mar. Drugs 2012, 10, 2795-2816; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview Wei Wang 1,2,*, Shi-Xin Wang 1 and Hua-Shi Guan 1,2 1 Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China; E-Mails: shixinwang87@ (S.-X.W.); hsguan@ (H.-S.G.) 2 Shandong Provincial Key Laboratory of Glycoscience Glycoengineering, Ocean University of China, Qingdao 266003, China * Author to whom correspondence should be addressed; E-Mail: wangweidragon@; Tel.: +86-532 Fax: +86-532 Received: 1 November 2012; in revised form: 26 November 2012 / Accepted: 29 November 2012 / Published: 12 December 2012 Abstract: Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety of antiviral activities. This paper will review the recent progress in research on the antiviral activities and the mechanisms of these polysaccharides obtained from marine organisms. In particular, it will provide an update on the antiviral actions of the sulfated polysaccharides derived from marine algae including carrageenans, alginates, and fucans, relating to their structure feat